CYRENE is a European project, funded under the Horizon 2020 Work Programme. It aims to enhance the security, privacy, resilience, accountability, and trustworthiness of Supply Chains (SCs) through the provision of a novel and dynamic Conformity Assessment Process (CAP) that evaluates the security and resilience of supply chain services, the interconnected IT infrastructures composing these services and the individual devices that support the operations of the SCs. In particular, the proposed Conformity Assessment Process will support, at different levels, SCs security officers and operators to recognize, identify, model, and dynamically analyse cyber risks. Moreover, it will support forecasting, treatment and response to advanced persistent threats and handle daily cyber-security and privacy risks, incidents and data breaches.