Global Supply Chains are a way of life for modern business, becoming more complex and integrated. The organizations that operate within the Supply Chains have become smarter and are not only heavily dependent on Information and Communication Technologies but are also interconnected for exchanging and sharing large amounts of data. Moreover, there is still no easy, structured, standardized and trusted way to forecast, prevent and manage interrelated and propagated cybersecurity vulnerabilities and threats, in a way that takes into account the heterogeneity and complexity of today’s Supply Chains. Therefore, there is a pressing need for devising methodologies, techniques and tools for the efficient evaluation and handling of security threats and vulnerabilities supporting all involved infrastructures for the provision of critical Supply Chain services. CYRENE comes to fill this gap for devising such methodologies, techniques and tools.